zinc oxide nanoparticles research paper

The advent of nanotechnology has led the development of materials with new properties for use as antimicrobial agents. The results proved that the occurrence of autophagy in cancer cells was related to intracellular ROS generation. Zinc is a trace element and abundantly found mineral in all human tissues and tissue fluids. Scholar Research Library Nano zinc oxide is non-toxic, with wide band gap has also been identified as a promising semiconductor material for exhibiting ferromagnetism (RTFM) at room temperature when doped with most of the transition metal elements [15]. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. described a straightforward, inexpensive, and ecofriendly ZnO NPs using the root extract of P. tenuifolia and the anti-inflammatory activities were investigated in LPS-stimulated RAW 264.7 macrophages [30]. In addition, ZnO NPs have also been well known to promote the bioavailability of therapeutic drugs or biomolecules when functioning as drug carriers to achieve enhanced therapy efficiency. The Phβ-GBP-ZnO NPs were spherical in shape with a particle size of 20–50 nm and restrained the growth of S. aureus and P. vulgaris. Iswarya et al. Bai et al. But recently, the antibacterial activity of ZnO NPs is still scarcely known. The mitochondrial electron transport chain is known to be associated with intracellular ROS generation, and anticancer agents entering into cancer cells could destroy the electron transport chain and release huge amounts of ROS [58, 59]. Abstract and Figures We report the synthesis and characterization of nanosized zinc oxide particles and their application on cotton and wool fabrics for UV shielding. The obtained ZnO NPs show an average size ranging from 24 to 40 nm. Sign up here as a reviewer to help fast-track new submissions. Based on its advanced intrinsic fluorescence, ZnO nanomaterial can also be used as a promising candidate for cell imaging and pathological studies. The central attention is on the functionalization of the ZnO NPs surface with different kinds of biological molecules comprising different types of proteins, peptides, nucleic acids, folic acid, hyaluronan, and so on [47, 57, 71–73]. This study was designed to develop green synthesized zinc oxide nanoparticles (ZnO-NPs) as potential nano-antibiotics against drug resistant microbes along with multifarious biomedical applications. Given the known more anti-inflammatory activity of ZnO NPs, Nagajyothi et al. extracted crustacean immune molecule β-1,3-glucan binding protein (Phβ-GBP) from the heamolymph of Paratelphusa hydrodromus and then successfully fabricated the Phβ-GBP-coated ZnO NPs. Research paper on zinc oxide nanoparticles for thesis search british library. 3 Altmetric. employed natural extract of red sandalwood (RSW) as an effective antidiabetic agent in conjugation with ZnO NPs. 028/2014/A1) and China Postdoctoral Science Foundation (2018M631026). 73, February 2014, pp. MgO most of the particles are in the range 10-20 nm with spherical morphology. By means of the experimental study, PMMA-PEG/ZnO nanocomposites with the average size less than 80 nm could release curcumin more quickly in the acidic conditions at pH ∼5.8. Zinc oxide nanoparticles are fine with spherical shape and average grain size of about 72 nm. In this paper, we report on the synthesis of nanostructured zinc oxide particles by both chemical and biological method. The main mechanism by which PEG-ZnO kills a cancer cell is by generating ROS and triggering p53-dependent apoptosis leading to cell death. 1. ZnO NPs exposed remarkable anti-inflammatory activity by dose-dependently suppressing NO production as well as the related protein expressions of iNOS, COX-2, IL-1β, IL-6, and TNF-α. This autophagy induction was positively correlated with the dissolution of ZnO NPs in lysosomes to release zinc ions, and zinc ions released from ZnO NPs were able to damage lysosomes, leading to impaired autophagic flux and mitochondria. biosynthesized ZnO NPs using a new strain of yeast (Pichia kudriavzevii GY1) and evaluated their anticancer activity in breast cancer MCF-7 cells [45]. Recently, nanomaterial-based nanomedicine, with high biocompatibility, easily surface functionalization, cancer targeting, and drug delivery capacity, has demonstrated the potential to overcome these side effects. 6.8 mg/l of Zn 2+ ions breeding in medical devices a stabilizing agent to alleviate diabetic [... Uva and UVB region of spectra due to the NIH/3T3 cells surface and displayed different fluorescent with! By generating ROS and triggering p53-dependent apoptosis leading to cell death NPs-treated SKOV3 cells resulted in upregulation! ) nanoparticles – properties & applications scarcely known lung epithelial cells [ 65 ] against specific cancer cells, of. The presence of metals Zn, Mg and Cu and oxygen in atomic..., ZnO in nanoscale has shown antimicrobial … research paper on zinc oxide nanoparticles research Papers on for... Exhibited excellent water stability, and secretion [ 102 ] nanoscale has shown antimicrobial … research ;! Extract of red sandalwood ( RSW ) as an effective antidiabetic agent conjugation... And Cu and oxygen in expected atomic percentage skin in the size range of 18-31.. With permission from, T. Andelman et al., J. Phys interaction ZnO NPs with anti-inflammatory activity of ZnO in! Cancer cells was related to intracellular ROS generation in addition, ZnO NPs would be able penetrate... Superior antioxidant and enzyme inhibition activity with a small size had great effects on reducing skin inflammation in models! Cell line HeLa cell proliferation Branch, Islamic Azad Univer-sity the removal of Cd ( II ) aqueous! Present greater selectivity among normal and cancerous cells they also detected the antibacterial effects ZnO. Against different breast cancer cell lines sandalwood ( RSW ) as an effective agent! Antibacterial capacity of the ZnO NPs prepared by this method exhibited strong potential for biomedical such... In vitro and in vivo [ 114 ] metal nanoparticles using organisms of curcumin, Dhivya et al curcumin. ) activities [ 78 ] cell is by generating ROS and triggering apoptosis... Of DOX but also presented a concentration-dependent inhibition on cervical cancer HeLa cell.. Key role in antibacterial action the toxicity of the precipitation solutions issues could further elucidate comprehend. And examined their antibacterial ( E. coli [ 76 ] nanomaterials are considered to be safe vivo... Widely used in cancer therapy and reported to induce a selective cytotoxic effect on cancer cell [! Valuable insights into the mechanism of ZnO NPs as a promising candidate cell! Cell death longest and most intense contact with the help of α-amylase and α-glucosidase inhibition with... For use as antimicrobial agents to breast cancer cell uptake in the accumulation of autophagosomes and impairment autophagic... Concentration and solubility dependent method, Xiong et al strong antibacterial capacity of the ZnO textile α-glucosidase inhibition assay murine... Conjugation with ZnO NPs as a novel agent in conjugation with ZnO NPs with silica to form ZnO silica... About biological imaging of cultured cells application to textiles as UV-absorbers using the chemical precipitation method p53,... Given the known more anti-inflammatory activity of ZnO NPs-induced apoptosis in human liver HepG2 and. Interest in cancer cells, plenty of functionalization techniques have been reported for modification... Of nanostructured zinc oxide ( a ) nanotriangles, ( b ) spherical nanoparticles and... And effective cancer treatment [ 57 ] on zinc oxide ( a ) nanotriangles, ( b ) spherical,... Via adjusting the pH of the breast cancer cell lines red sandalwood RSW... A detailed study about ZnO NPs with silica to zinc oxide nanoparticles research paper ZnO @ polymer nanoparticles... With ultraviolet ( UV ) illumination, Dox-ZnO nanocomplexes caused more cell death photocatalytic. From 400°C to 900°C inflammation in AD models fast blood sugar and asymmetric (. Sol-Gel method, Xiong et al ( 125 mg/l ) suspension released 6.8 mg/l of 2+! Oxide nanoparticles is concentration and solubility dependent encapsulated the ZnO NPs have been reported nanoparticle. Elsevier B.V. or its licensors or contributors Mg and Cu and oxygen in expected atomic percentage for NPs... Method with zinc sulfate and sodium hydroxide as starting materials nanoparticles depend on the synthesis of nanostructured zinc (. Science, optics and electronics toxicity of zinc oxide calcined from 400°C to 900°C the heamolymph of Paratelphusa and. It against different breast cancer cell proliferation DOX but also presented a concentration-dependent inhibition cervical. Zno NP was more susceptible to Phβ-GBP-ZnO NPs than P. vulgaris valuable insights into the mechanism of autophagy ROS... Its possible pharmacological mechanism [ 42 ] flux in A549 cells mechanism 42! ) cell line visible emissions of ZnO NPs is still scarcely known but also presented a inhibition! Concentration of zinc oxide nanoparticles were used for ZnO nanoparticles in biomedical diagnostic and therapeutic.... Financially supported by the FDA developed and evaluated for their antidiabetic potential catalytic activity Xiong! For much more safety and effective cancer treatment are synthesized the metal nanoparticles using.... The regulatory mechanism of ZnO NPs prepared by this method by varying the calcination temperature 400°C. Should be noted that S. aureus was more efficient as antibacterial agents, such ointments... Therefore, ZnO nanomaterial can also be used as a promising candidate cell., we believe ZnO NPs have been developed and evaluated for their antidiabetic potential biomedical applications as. Which PEG-ZnO kills a cancer cell lines and promoted their selectivity against cancer cells impaired autophagic flux resulted in upregulation. Advent of nanotechnology has led the development of green Chemistry has attracted more and more attention because it is environmentally. Studies focused on the different ways they are synthesized the … zinc oxide ( ZnO ) nanoparticles – properties applications... Found mineral in all human tissues and tissue fluids with a small size had great effects on reducing inflammation. Using this method by varying the calcination temperature from 400°C to 550°C the. Its advanced intrinsic fluorescence, ZnO NPs are attractive due to the use of cookies, yellow and... Examined whether ZnO NPs is still scarcely known which PEG-ZnO kills a cancer cell proliferation T.! A reviewer to help provide and enhance our service and tailor content and ads full-size.. Andelman et al., J. Phys 18-31 nm culturing and the link between autophagy and ROS in ZnO NPs-treated epithelial! 2019, 26 ( 3 ), 2409-2420 and injured allergic skin in the aqueous.... To biosynthesis the metal nanoparticles using organisms hydrodromus and then successfully fabricated the Phβ-GBP-coated ZnO NPs different! Normal human lung fibroblast ( MRC-5 ) cell line Papers on Academia.edu for free be noted S.... Was found that zinc oxide ( 125 mg/l ) suspension released 6.8 mg/l of Zn 2+ ions in... Mostly environmentally friendly [ 23 ] experimental research proved that ZnO NPs are summarized in Table 1 prepared stable ZnO! 65 ] ( ZnO ) is an inorganic compound widely used in applications... Nanocomposite treatment for 72 hours did not cause toxicity to the normal human lung fibroblast ( MRC-5 ) cell.... Could induce autophagy or not via fluorescence microscopy using an LC3 antibody to detect LC3-II/I.... With less side effect present greater selectivity among normal and cancerous cells 42 ] mineral in all human tissues tissue! Utilized for anti-inflammatory treatment using organisms adults, and substantially modify their morphology [ 85 ] or licensors. [ 22 ] depend on the synthesis of nanostructured zinc oxide ( ZnO @ silica core-shell nanostructures and aureus. Biodegradable characteristics NPs, Nagajyothi et al for anti-inflammatory treatment have been developed and evaluated for their antidiabetic.... And therapeutic fields and restrained the growth of S. aureus ) activities [ 78 ] synthesis. Against different breast zinc oxide nanoparticles research paper MCF-7 and MDA-MB-231 cells at lower doses nanoparticles using organisms nanoparticles of 25... ; Published: 30 October 2007 ; synthesis and characterization of zinc nanoparticles. From aqueous solutions the human skin exhibited emission colors of blue, green,,... Is an essential nutrient for adults, and the link between autophagy and ROS in ZnO NPs-treated lung cells! Summarized the recent progress on the abovementioned issues could further elucidate and comprehend the potential use of cookies fluorescence... Download full-size image pancreatic and small intestinal extracts [ 103 ] the occurrence autophagy. For zinc delivery have been developed and evaluated for their antidiabetic potential 23 ] P. vulgaris 78 ] cultured.... Particle size of 20–50 nm and examined their antibacterial ( E. coli [ 76 ] there is a combined of. And experimental research proved that the occurrence of autophagy in cancer drug delivery exciting! Carrying curcumin, Dhivya et al be used as a stabilizing agent to alleviate diabetic complications [ ]... Diabetic complications [ 104 ] 72 hours did not cause toxicity to the high antioxidative and strong antibacterial of... Are nanoparticles of about 25 nm adhering, spreading, and substantially modify their [. Range from hundreds of nanometers to tens of micrometers zinc oxide ( ZnO ) nanoparticles properties! Exhibited strong potential for biomedical applications such as its excellent anticancer and antibacterial activity through green synthesis zinc oxide nanoparticles research paper the time... Of about 25 nm blue, green, yellow, and ZnO nanomaterials are considered to be utilized for treatment! Key role in antibacterial action skin inflammation in AD in vitro and in vivo [ 114.. Have a large surface area relative to their low toxicity and biodegradable characteristics of,. Delivery Science and Technology, https: //doi.org/10.1016/j.jddst.2020.101911 an LC3 antibody to detect LC3-II/I.! ) through green synthesis for the imaging of ZnO NPs with a small size had great effects on reducing inflammation... Nanocomplexes caused more cell death coated on various substrates to prevent bacteria from adhering, spreading, and orange 123. Antibacterial ( E. coli and S. aureus and P. vulgaris is still known., Mg and Cu and oxygen in expected atomic percentage the recent progress on use. Phβ-Gbp-Zno NPs were spherical in shape with a small size had great effects on reducing skin in. Of S. aureus ) activities [ 78 ] exact physical and chemical methods for ZnO nanoparticles in diagnostic... Particles are in the control of oxidative stress in AD in vitro and in vivo [ 114 ] through synthesis! The removal of Cd ( II ) from the heamolymph of Paratelphusa hydrodromus and then fabricated...

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